Skin manifestations of systemic diseases involve dermatological symptoms that reflect underlying internal health conditions. Conditions such as diabetes, lupus, and thyroid disorders often present with specific skin changes, aiding in diagnosis and management. Recognizing these manifestations is crucial for comprehensive patient care. This book explores the various ways systemic illnesses present through dermatological signs, discussing the pathophysiology, clinical features, and diagnostic significance of skin symptoms related to internal diseases. It provides valuable insights into the connection between systemic health and skin conditions, serving as a valuable guide for dermatologists, internists, and healthcare professionals aiming to identify and manage systemic conditions through their skin manifestations.