This book presents the main research efforts of EURO-TELEPATH, an initiative of the European Corporation in Science and Technology (COST) Action, IC0604. This program began in November 2007, and ran until November 2011. Its aim was to develop the standards and solutions necessary to represent, interpret, browse and retrieve digital medical images, while preserving their diagnostic quality for clinical purposes, education and research. At the end of the project, the most relevant researchers in the field of digital pathology – many of whom had been active members of EURO-TELEPATH – were asked to contribute to a book which would compile the main research efforts of the European COST Action consortium.