This book presents the proceedings of DSIE2021, the 2021 International Symposium on Design Studies and Intelligence Engineering, held in Hangzhou, China, on 27 & 28 November 2021. This annual conference invites renowned experts from around the world to speak on their specialist topics, providing a platform for many professionals and researchers from industry and academia to exchange and discuss recent advances in the field of design studies and intelligence engineering. The 210 submissions received were rigorously reviewed, and each of the 50 papers presented here was selected based on scores from three or four referees. Papers cover a very wide range of topics, from the design of a pneumatic soft finger with two joints, and the emotion of texture, to the design evaluation of a health management terminal for the elderly, and a multi-robot planning algorithm with quad tree map division for obstacles of irregular shape.