This book presents the proceedings of the 16th annual conference on Health Informatics Meets Digital Health (dHealth 2022), held on 24 and 25 May 2022 in Vienna, Austria. In keeping with its interdisciplinary mission, the conference series provides a platform for researchers and decision makers, health professionals and healthcare providers, as well as government and industry representatives, to discuss innovative digital health solutions to improve the quality and efficiency of healthcare using digital technologies. The book includes 42 papers covering a wide range of topics and providing an insight into the state-of-the-art of different aspects of dHealth, including the design and evaluation of user interfaces, patient-centered solutions, electronic health/medical/patient records, machine learning in healthcare and biomedical data analytics.