This book introduces licorice as alternative medicine, its application in the industry, licorice ingredients and their antioxidant; proposes the possible molecular mechanism by which licorice ingredients induce anti-inflammatory, antifibrosis, antihepatitis, and antileishmanial activity. The book is also aimed to highlight the current understanding of the mechanism of bioactive constituents of licorice, which potentiates them as antileishmanial agents. Additionally, it also brings to light the importance of folk medicine in curing diseases and thereby gives impetus to explore ancient medicines and their mode of actions to use them progressively to cure diseases.