In fact, we have witnessed the birth of new analytical methods that play an essential role in biotechnology. Knowing the appropriate applications of various analytical techniques used in biotechnology, makes the experiment more easier and let the researcher obtain a better result which also reduces the time period of experiment by eliminating the trial and error methods. Along with the knowledge of application of the analytical technique, the researcher also should have the knowledge of the sampling techniques for the analytical instruments as it is one of the deciding factors to choose a specific technique for the analysis. This book focuses on enhancement technology development by promoting cross-disciplinary approaches directed toward instrumental methods in biotechnology.