Packed with comprehensive tools and techniques, this book presents to the reader a detailed, yet easily accessible, description of the whole field of gene therapy. This book discusses methods currently used in preclinical and clinical gene therapy describing the basic biology and potential application of viruses as gene transfer reagents. Representative strategies are provided for gene targeting and for viral or nonviral gene delivery in cancer therapy, as well as a significant number of clinical protocols for the development of novel cancer gene therapies.